A friend from Bull’s past enlists his services to help convince a jury that a domestic abuse survivor who shot her husband in his sleep is not guilty of murder because she feared for her life and the life of her unborn child.

Bull confronts his guilt over closing his psychiatric practice to start TAC when his former patient, a young woman who is a clinical sociopath, goes on trial for killing her brother. When Bull and Benny’s client has no memory of the crime due to her mental condition, they enter a "Not Guilty by Reason of Insanity" plea and aim to seat jurors that are sympathetic to mental illness.

Bull helps mount a defense for Taylor’s brother-in-law, Ralph Kelly, a prison guard charged with manslaughter for the drowning deaths of two inmates in the middle of a hurricane. During the trial, Bull aims to convince the jury that his client tried to prevent a “greater harm” when he abandoned his prison command to evacuate his own family.

Bull represents a large insurance company and its clients, married pizzeria owners who are being sued for negligence by a teenager who was injured while climbing their rooftop signage. As the trial gets underway, Bull realizes the case has no clear winners, as the small business owners could lose their livelihood, the plaintiff may never walk again and the insurance company refuses to settle

Bull and Chunk represent an emergency room doctor being sued for malpractice after she ignored direct orders to save one near-death patient in favor of helping another who was also critically injured.