Bull helps a doctor who crossed state lines to purchase a marijuana-derived oil to treat her patients in Virginia, where the oil is illegal. But the case is complicated when Assistant U.S. Attorney Sylvia Banner has the DEA arrest her for possession with intent to distribute.

Bull returns to work following his heart attack with a new rich client for the firm to represent: an insurance company being sued by a dying mother for denying coverage of her liver transplant.

Bull mounts the defense of New York City’s chief medical examiner, Julia Martin, when she is charged with tampering with evidence tied to the years-old case that made her career. As Bull worries that his client’s propensity for brutal honesty could affect her chances in court, he aims to fill the jury with individuals inclined to believe she made a mistake rather than conspired to tamper with forensic evidence.

Bull helps mount a defense for Taylor’s brother-in-law, Ralph Kelly, a prison guard charged with manslaughter for the drowning deaths of two inmates in the middle of a hurricane. During the trial, Bull aims to convince the jury that his client tried to prevent a “greater harm” when he abandoned his prison command to evacuate his own family.

As Bull prepares for fatherhood, his work at TAC suffers without his top attorney, Benny, who quit in reaction to Bull’s romantic reconnection to his ex-wife and Benny’s sister, Isabella. In addition, the team faces a difficult time in court as they mount a defense for a young bartender on trial for involuntary manslaughter.

Bull is hired by a doctor, Samir Shadid, who’s accused by the Manhattan U.S. attorney of bribing his way into college, just as Bull’s ex-wife, Isabella, is due to give birth. As Bull waits for Izzy to go into labor, he contends with the trial’s national news, due to its connection to a high-profile college admissions conspiracy case.

Bull and Chunk represent an emergency room doctor being sued for malpractice after she ignored direct orders to save one near-death patient in favor of helping another who was also critically injured.

When Bull handles the negligent homicide defense of a building owner accused of killing tenants by carbon monoxide poisoning, the case rocks Bull and the TAC team to their core. Also, TAC’s trial defense is made more difficult when the ADA prosecuting the case is Chunk’s ex-boyfriend, Rob Jones, someone very familiar with Bull’s tricks; and Taylor is forced to reevaluate her work-life balance when she gets shocking news about her son.