When Bull and Trial Analysis Corporation (TAC) help a young woman fight a drug patent lawsuit, they’re forced to travel to Callisto, the small Texan town where Bull suffered the only trial loss of his career.

After a skybridge collapse kills fifteen people, Bull helps prosecute a New York real estate tycoon (and his landlord), only to discover he's a sociopath who will do anything to win, whether it be hiring one of Bull's toughest opponents as his attorney, bribing the mirror jurors, or shutting down the power in TAC. Meanwhile, Benny learns that he is being investigated by the DA's office.

The bond between Chunk and Bull is tested when TAC takes on as a client the prime suspect in the death of Chunk's fashion mentor killed during her own show. Meanwhile, Bull rekindles a romance with one of his toughest opponents.

When Bull joins the district attorney in a case against Kara Clayton, who claims she killed her billionaire husband in self-defense, tensions run high when he learns that his on-again, off-again romantic interest, Diana Lindsay, is defending the widow. Also, Chunk makes a decision about his future.

Bull and his on-again, off-again romantic rival, Diana Lindsay, join forces to create two separate but collaborative defense teams when Diana's niece and her husband are charged with armed robbery. As the trial gets underway, Bull's reunion with Diana is strained by his new post-heart attack regimen.

Bull's romantic rival, Diana Lindsay, jeopardizes her career when she secretly has Bull come to Texas to assist a couple fighting against her former client for custody of their grandchildren.

Bull and Izzy experience marital discord when Bull has TAC lead the defense for Diana Lindsay, his ex-girlfriend who’s accused of killing her lover’s wife. Also, personal conflicts abound for the TAC team when Chunk finds himself defending Diana in court against his boyfriend and prosecutor, Robert.