After a surprise attack, Lorenzo and Giuliano search for the culprits. The trail leads the brothers to the Pazzis, but treachery lies closer at hand.

Lorenzo's power play comes at a cost and stirs up outrage. With leadership comes sacrifice as he travels to Rome and weighs an advantageous match.

Lorenzo aims to strengthen ties with the Pazzis and proposes a treaty with Venice. Clarice appeals to Lucrezia and learns the way to Lorenzo's heart.

As forces threaten a fragile alliance, the Pazzis embark on a murderous plan to destroy the Medicis while Lorenzo seeks to make peace with Rome.

The day of reckoning arrives as the circle of conspirators tightens around the Medicis during Mass, and rivals attempt to take control of Florence.