The Busbys are back & life is more chaotic than ever! Adam & Danielle have their hands full chasing after their 15 month old quints. And when a doctor recommends an extreme medical procedure for one of the girls, the Busbys face a difficult decision.

The Busbys take a road trip to help Mimi with her garage sale, but Danielle is shocked by news from her mom. Meanwhile, Adam and Danielle discuss a recommended eye surgery for Hazel.

Hazel undergoes eye surgery, causing Adam and Danielle to wait anxiously for the results; Blayke prepares for kindergarten and Mimi officially moves in.

When Danielle catches the flu, Mimi struggles to take care of 5 babies on her own. Adam plans a 10-year anniversary surprise for Danielle. Later, when Danielle gives a speech for the hospital, she faces the painful past of having premature babies.

Danielle and Adam explore sending the quints to nursery school, but when one of the them isn't allowed to go, the Busbys face the difficult decision of splitting the girls up. As for Mimi, living under the Busby roof has begun to take a serious toll.

It's Halloween, but before the Busbys can celebrate the Quints' first trick-or-treat outing, they have to find costumes, shop for pumpkins and get the new house ready for a Halloween party, all while making a final decision on a $100,000 investment.

It's the quints' first family vacation! But with five toddlers running wild, it may feel more like work than vacation time for Adam and Danielle. Meanwhile, Adam struggles to tell his brother-in-law, and boss, about the new business he's starting.

It's Thanksgiving at the Busby household! Adam & Danielle decide to host 20 people but soon realize they have bitten off more than they can chew. Meanwhile, Hazel has a major breakthrough and Adam & Danielle push Mimi to consider apartment living.

When a talk show asks the Busbys to make a live TV appearance in New York, the family heads to the Big Apple. But traveling with 6 kids is as difficult as it sounds! And a last-minute trip to the doctor has Danielle and Adam concerned about Hazel.