Psychology Professor Jackson Cooper Coop encounters a beautiful mystery woman, Natalie, he thinks could be his soulmate. After she disappears without giving Coop her full name or number, his best friend Carter tries to help him locate her.
Coop and Carter resort to social media to find Natalie, while his nosy neighbor Diane disapproves of their tactics. Carter helps Diane's nephew, Shadrach, with a personal problem. Coop's assistant, Sophie, hires an event planner.
Coop and Sophie go to a psychology dept. retreat at the home of the dept. head, Dr. Harty, who also happens to be Scarlet's father. Carter returns to his childhood home and is forced to juggle his overbearing mother, Kitty, and his first love, Holly.
Carter hires Holly's sister Zoe to assist him with his latest project, his memoir. Shadrach has a run in with a bully. Coop tries to take his therapist, Ira's advice and put his past to rest by squaring things with his ex-fiance, Lisa.
After an unexpected development in her personal life, Sophie gets drunk at work on the day of the department gala. Coop rushes to cover for her and in the process encounters the event planner, Natalie.