Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event during weight loss surgery recovery may separate them forever.

At 670 pounds Ashley must live in her parents' home with her husband. Desperate to save her life and her marriage, she decides it's time for a drastic change. Can weight loss surgery save her life?

Cynthia is a 610-lb single mother raising five kids. She's been focused on her children, but now realizes what her death would mean for them. As she battles her emotions & the pressures of life, she is forced to fight harder to save her own life.

Weighing over 600-lbs Kirsten is close to losing her mobility. While she's trying to get control of her obesity she's also in danger of losing her troubled son. She must regain her health in order to be the best mother she can to care for her son.

At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but they are reluctant based on past failures. Each meal threatens Erica's worst fear coming true; dying the same way she lives, alone & surrounded by food.

Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her home for a weight loss journey under the strict authority of her niece in order to regain her life.

Michael's massive 632lb body has left him completely dependent upon his family. If he doesn't learn to control his anger issues around food, lose weight, and address the root of his issues, then he will remain in jeopardy of losing everything.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey to Houston, Texas, with the hope that bypass surgery can save his life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs. They're so massive with severe lymphedema, that gastric surgery is her only chance of survival. Will this mother & grandmother ever gain control of her overeating?

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can't stand each other, their father packs up the family to travel across the country to seek help, desperate to save both his sons' lives.

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses on a new career instead of his diet. With neither brother close to being approved for life-saving surgery, time is quickly running out for them.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300 lbs. but still can't walk. Ashley is struck with sudden paralysis. Sarah and Roger prepare for skin removal surgery.

Brittani will have to endure two more painful surgeries to achieve her ideal body. Will Sean finally make a break from his mother's over-protective care? And Annette and Calisto prepare for skin removal surgery.

Surgery enables Teretha to finally return to family in Detroit, but it soon threatens to undo all the progress she's made. After his weight loss surgery, trucker Chad gets back on the road, but the job is putting any further weight loss in peril.

After losing 250 lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki's progress goes off track. And Mary and Lora prepare for skin removal surgery.

A woman's weight-loss journey is in danger of going off track following the sudden loss of her son; a woman embarks on a plan to win approval for skin surgery.

Charity manages to lose over 400 pounds, but her daughter Charly becomes dangerously obese. Devastated by the death of her husband, Elroy, Milla must find a way to finally qualify for gastric bypass.

A man who weighed 800 pounds is engaged, but must continue to lose weight; a woman is on the verge of independence if she qualifies for skin surgery.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the next skin surgery. Chay revealed to her family she was transgender but living life as an overweight woman; can she stick to her weight loss journey?