Earthworm Jim fires Peter Puppy after he let Professor Monkey-For-A-Head get away. Jim auditions new sidekicks while he attempts to rescue Princess What's-Her-Name from Psy-Crow.

Due to a printing error, one of Jim's pop-up story books has the secret of universal conquest, and Evil the Cat will do anything to get it.

The League of Superheroes runs out of sugar, so Jim flies of to La Planeta de Agua to get some. Bob the Killer Goldfish takes advantage of Jim and steals his super suit so he can conquer the Earth.

A freak accident with a photocopy of Jim's face leads to the creation of Evil Jim. Jim must bust out of prison and stop Evil Jim from destroying the Turlawk shopping mall.

Evil the Cat releases a beast named "Rosebud" to assist him in destroying the universe. However, Rosebud is a little too mellow to go with Evil's sinister plot, even though he knows "The Great Secret of the Universe."

Professor Monkey-for-a-Head and Psy-Crow steal Jim's super suit, and Jim uses a weak duplicate to try to get it back.

Princess What's-Her-Name finally dethrones the evil Queen and takes her place as the ruler of Insectika. Unfortunately, being a stuck-up debutante is not the Princess' cup of tea.

Bob the Killer Goldfish resurrects the god of all fish to help him conquer the universe. But, this evil piranha only wants to mangle and devour "The Great Worm Spirit." Jim and Bob form an uneasy alliance to stop the fish from eating the great worm and destroying the universe.

Jim has put up with Peter's monsterous alter-ego long enough, and seeks to cure him. However, the cure might turn Peter into a plain ol' dumb dog.

Evil Jim creates evil opposites of the Princess and Peter, which have some major flaws.

Bob, the Killer Goldfish creates an device that sucks the "evolutionary energy" out of anything that it wraps around. Jim and Peter are made into idiots by it, and remain idiots for a large percentage of the episode.

Psy-Crow is tired of Queen Slug-For-A-Butt giving him orders, and seizes the throne of Insectika. Since Psy-Crow is an even worse ruler, Princess What's-Her-Name, Jim, Peter and Mrs. Bleveredge, must stop Psy-Crow and put the queen back on her evil throne.

Evil the Cat and Malice the Dog work together to summon The Fiend Which Dares Not Speak Its Name.

The queen is mighty peeved at Psy-Crow for dethroning her in the last episode, and demands that he destroy Jim once and for all. After gaining superpowers from drinking too much espresso, Hyper Psy-Crow battles with Jim, resulting in the destruction of the universe.

Professor Monkey-For-A-Head is using a special peanut butter formula to turn everyone into a witless monkey. However, Jim is more concerned about how badly his show's ratings are slipping, and tries to get more people to watch through a technology called "Earthworm Interactive."

Professor Monkey-for-a-Head builds a doom machine for Queen Slug-for-a-Butt that transports Jim to an alternate universe. The alternate universe has several characters from the regular universe.