The Muppets have a new show at the KMUP network and a new host, Clifford (no one else wanted the job). In need of a big star for the first episode, Clifford accidentally agrees to both Michelle Pfeiffer and Miss Piggy guest staring without them knowing.

As the show goes on with Billy Crystal, new securtity guard Bobo the Bear keeps other guests from entering the station, including a jazz band for the show's last number.

Johnny seems thrilled when Tony Bennett guest stars, but he gets nervous about working with the famous singer and has difficulty performing.

The Muppets have even more pressure to make the show a success when a crazed individual known as the Mad Bomber threatens to blow up the studio if the ratings drop below fifty.

Old school friends, Gonzo and Jason Alexander, attempt to bring their musical onto the show. But their disagreements could end the project.

Miss Piggy is due to be in the show's closing number, but she is late for various reasons, which causes some panic for Clifford and the others.

A freak incident in the elevator leaves Martin Short in a tight squeeze and later some delicious spaghetti sauce leaves him feeling large.

Pierce Brosnan is depressed over the fact that he isn't as debonair as his James Bond character, but he finally gets a chance to prove himself when the Crustacean Liberation Army attempts to take the Muppet Studios hostage and only he can save them.

The KMUP studios have been bought by a new owner, Ernst Stavros Grouper. He believes that the Muppets are just not hip enough, and he wants to make some changes. Coolio and Don Rickles guest star; Ed McMahon, Bernard Shaw, and Fred Willard make cameo appearances.

A crazed robot of President Lincoln runs amuck throughout the Muppet Studios while Clifford repeatedly tries to grab a kiss from Paula Abdul.