Jenner is hospitalized with a mysterious virus infection and is growingly suspicious towards Stanley. Meanwhile, Rio is back in Buenaventura and gets aquainted with Allison Stratton, the new manager of the Parador Hotel. Allison detests Wiley and disagrees with the way he and Rio conduct their flights. She wants them to improve the look of the airport and give the tourists a better first impression so they'll want to stay at her hotel. Rio refuses to believe his father is dead and one night he is approached by a mysterious woman. She gives him Frank's pin and claims Frank gave this to a woman in trouble who needs Rio's help. Later, when Rio talks about the mystery woman, Pablo the mechanic tells him this must be 'la curandera', a strange woman who suddenly appears when people are in need of help. Her real name is Alma. The corrupt Stanley arrives in Buenaventura and meets up with his associate, State Department official Edward Furman. They go after Isabella, who is in possession of Hec

Shortly before the local election is to take place in Buenaventura is to take place, the political situation is tense. The governement - led by the brutal General Carlato - desperstely tries to hold on to the power, so a group of revolutionaries take over the Parador Hotel; the hostages including Alison and her visiting (and rather unsympathetic) father. Rio faces a difficult task as he tries to solve the conflict peacefully.

Lucie Ortega, a beautiful nightclub singer at the Club Saludos, contacts Rio for help. She needs to leave Buenaventura immediately to be with her sick mother in the Andes but cannot leave unless her boss at the club pays her the 75 million Pesos he owes her. Rio - not knowing that Lucie has been sent to him by the always unreliable Furman - naturally agrees to help an attractive damsell in distress, and goes to the Club Saludos and gets the money from Lucie's boss, Mesarigos. Shortly afterwards, Mesarigos is found murdered, and Lucie and the money have vanished. Rio, who was Mesarigos' last visitor, gets charged with murder.

Multi-millionaire William Dayton (a friend of Alison's father) arrives in Buenaventura to discuss taking over Rio's route. Rio, however, is more concerned about why local villagers are disappearing at an alarming rate. When his good friend Alma, the local medicine woman, disappears too, a concerned Rio enlists Wiley's help. They uncover a conspiracy to kidnap villagers to take their organs and sell them on the black market.

The American Ambassador in Buenaventura is blackmailed by corrupt industrial Mark McCormick. McCormick demands that his son, Peter, be given this political post. Peter himself, however, has no interest in a political career. All he wants is to be happy with his fiancée Jennifer. Jennifer is an old flame of Rio's, and when the two of them meet, the old passion is re-ignited.

Rio and Wiley are ordered by Furman to protect the life of Ramon Estrada, a filthy gangster in Buenaventura, who has made enemies in the mob. Furman wants to protect him because Estrada has proven himself to be a useful snitch. An assassin is coming to Costa Perdida to end his life. Wiley sets up secret video cameras in all the rooms at the Parador Hotel to try and figure out which of the new guests is the killer. But Estrada has many enemies, and finding the real assissin turns out to be difficult.

Fantini, the world champion in 'Ultimate Fighting' shows up in Buenaventura wanting to buy the whole island to turn it into a holiday paradise. He uses brutal violence to reach his goal but gets challenged by Rio and Wiley.

In a park, a teenager named Henry witnesses a diplomat being assassinated. This puts Henry's own life in jeopardy: the government is dead-set on avoiding a political crisis and want to pass off the diplomat's death as a suicide. Rio and Wiley are brought in to bring Henry to safety but he gets kidnapped. Rio does all he can to rescue the boy.

Wiley suddenly faces a problem he has never encountered before: the experienced pilot is suddenly afraid of flying! A puzzled Rio brings Wiley to see Dr. Veronica Brady, a sexy psychiatrist. Veronica discovers that Wiley is under the influence of the dangerous drug Phanx Am. But how has Wiley gotten this drug in his body?

A left-wing extremist group rob a money transport and get away with printing plates for $100 bills. Rio and Wiley are ordered to seek out the robbers in their hiding place in the jungle. However, both Rio and Wiley end up captured, and learn they will face an execution squadron tomorrow...

Otani, a corrupt member of the OSI, sends out a group of soldiers to track down and kill Rio's father Frank, who is hiding in the jungle. Rio manages to locate his father before the soldiers, and finds Frank badly wounded in a hut. Frank reveals the true for why 'Operation Jaguar' failed, which is the reason he has gone in hiding.

An enormous hurricane threatens Costa Perdida. Rio and Wiley bring the villagers to safety, while they themselves take cover in a safe building. Suddenly, Rio's arch enemy, ex-OSI Officer Henry Stanley shows up. Will Rio finally be able to properly confront the traitor once and for all?