Former war hero and diplomat Frank Arnett is working for the organization OSI (Organization for Strategical Intervention), which battles drug trafficing in Central- and South America. Currently, Frank leads a mission called 'Operation Jaguar', which includes getting Hector Ramirez - courier between the drug cartel and the corrupt government Buenaventura - brought to America along with his cartel ledgers that can bring the bad guys down. Hector's only demand is that his girlfriend Isabella must be taken to America as well. Frank requests that his son, Navy pilot Rio Arnett, be brought in to help with the mission. OSI director Willard Jenner okays Rio's involvment but Henry Stanley, another important OSI figure, is vehemently oppsosed to the idea. Rio goes to Buenaventura and discovers that on the mission he'll also be working with his old pal Wiley Ferrell. Wiley briefly shows Rio around, including the Parador Hotel, the only hotel around which is run by the beautiful Allison Stratton.

Costa Perdida is struck by a virus epidemic. The government is doing nothing to stop the disease. On the contrary, they are doing all they can to cover up the epidemic. The only ones battling the deadly killer-virus are Rio, Wiley and sexy epidemic-expert Dr. Harley Shaw. Suddenly, Rio starts getting the symptoms of the disease...