Grad tries to persuade a hesitant Kronk to perform a double mastectomy on a healthy woman does not have cancer but who does have the gene for breast cancer and a family history of the illness. Austin struggles to get a reluctant Sara into an exclusive girls school. Nyland returns to work following his accident and throws himself into trying to identify a severely beaten and comatose young woman.

Gang warfare breaks out in the E.R.; Kate refuses to perform a heart transplant; Billy and Diane get back together.

After the mysterious death of a seemingly healthy 15 year-old Dr. Wilkes decides to investigate. A lesbian wants her lover to die with dignity and fights her family to get her wishes.

A cardiologist in NASA's Doctors in space program has a heart attack and Kate takes the doctors place in the program. Dr. Shutt has a patient who needs to tell his father, an Orthodox Rabbi, that he is gay.