A doctor with Tourette's Syndrome is brought to Chicago Hope to operate on an infant with a severe heart defect. A patient comes into the ER with, what he claims to be, Albert Einstein's brain and gives it to Dr. Wilkes. A woman is using plastic surgery to make herself look like a Barbie Doll.

Dr. Hanlon must fight against her department heads when they decide they no longer want her to perform pro-bono operations. Dr. Alberghetti tries to help a young man with a staph infection.

Shutt's patient wakes up after being in a coma after 15 years. A man is denied health coverage, after saving Miller's life.

Rumors fly that the hospital is about to be sold again; a man seriously injured in an accident wants to be the guinea pig for the computer program he's invented that can help him move again.