The team celebrates the opening of its new headquarters after 10 years of working out of trailers. Titus has received his paramedic license and his long time partner, Dan, must adjust to their new shared roles in a variety of calls. New to the team, Arcady and Ted, get to know each other's styles in their first shifts together.

In a night filled with multiple shootings, Holly and Nick must search for a gunshot victim that has gone missing. Meanwhile, Titus and Dan tend to a man stabbed multiple times. Keeley is heartbroken about the shooting tragedy in Orlando and is intent on participating in the city's upcoming pride march.

Working together for years has turned Titus and Dan into great friends. On their shift, they come across people who are the victims of crimes perpetuated by those close to them. On calls like these, when they become more than just emergency medical technicians, they are counselors and therapists. They will do everything possible to steer some troubled people in the right direction.

Every night, the members of the Nightwatch are reminded in new ways to be thankful for what they have. Titus and Dan resuscitate an overdosing drug user just before all hope is lost. Brooke and Landon tend to a young girl with congenial heart failure. Later, a team of firefighters contain a fire before it can wreck havoc. Things get a little bit lighter when Titus and Dan learn that a familiar patient is also a secret admirer of Holly.

Not all tragedies are created equal and tonight, when the men and women of New Orleans get word that one of their own has been seriously injured, they all reflect on the risks they take. Other calls during the night mirror that reality. A small party was thrown into chaos by armed intruders and a bar fight ended with a good samaritan getting seriously wounded trying to break up the fight.

Bystanders assist the first responders at a restaurant in the French Quarter and at the scene of a car accident; a tourist has to be coaxed into going to the hospital.

A woman in a disagreement with her boyfriend tells police a bizarre story; a suspected purse snatcher running from the authorities takes a break to finish eating some chicken strips; a tarot card reader suffers from dehydration.

The brother of a paramedic gets sucker-punched; best friends get into an accident; one of the newest members of the Nightwatch comforts a suicidal patient, then reflects on the bonds he has forged during his first year in New Orleans

The New Orleans EMTs receive calls from every direction, from gunshot victims to seizures to a moped rider playing Pokemon Go.