Maximilian's death leaves the Empire throne vacant. Francis I and Henry VIII want it, but Margaret of Austria will be Charles' best ally in the race.

Charles is the new emperor, but his fight with Francis I is not over. Meanwhile Hernan Cortez and Moctezuma meet.

While Charles is away in Europe, Commoners rise in arms in Castile.

Charles is finally crowned Emperor by the Pope, but joy is quickly followed by tragedies.

Both Charles and Francis are getting to the end of their lives.