Christa saves a woman's life and then pleads with Neal to perform a surgery that will save the patient's reproductive future. Meanwhile, Mario gets into a fight with a patient after he delivers a diagnosis that could end the man's hockey career.

The doctors work 36 consecutive hours in code black and must deal with a distraught mother of two sons who were in a devastating car accident. Meanwhile, Mario bullies Angus into performing an unnecessary operation and lets Angus take the blame when Leanne finds out.

A new surgical attending Cole Guthrie joins Angels Memorial with the help of his estranged father and clashes with Leanne over their contrasting approaches to medicine. Christa has a crisis of confidence in the middle of a procedure on her first infant since the loss of her son.

Neal clashes with his neurosurgeon father over how to treat his gravely ill mother, whose mysterious symptoms force Angels Memorial to quarantine Trauma One.

Angus utilizes his background in psychology when a woman cannot remember how she injured herself and others; Christa bonds with the mother of a patient with cystic fibrosis.

Christa must handle all emergencies at Angels Memorial that happen outside the emergency room; Malaya arranges a bone marrow drive for Carla; Leanne turns down a date.

Heavy fog at the scene of a massive multi-vehicle accident puts the doctors in danger; Jesse's confidence has taken a hit; Carla's condition turns critical.

As the doctors treat patients from the chaotic multi-vehicle accident, a love triangle begins to build between Mario, Angus and Heather. Also, when Malaya learns that Carla is at the hospital, she goes against Carla's wishes and stays by her side during the delivery of her baby. Shiri Appleby guest stars.

Angus' older brother, an "all-star" ER doctor, tries to secure a position at Angels Memorial. Meanwhile, Christa's romantic feelings towards Neal begin to grow; and Malaya deals with a patient who is obsessed with her.

After a violent incident inside the hospital results with some grave injuries, the doctors are questioned. Christa and Neal admit their relationship to human resources.