Rosewood’s partnership with Villa faces an uncertain future when she’s paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can’t shake the feeling that his “replacement” knows more about the victim’s narcotics business than he’s letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks, is brought in to help with the investigation and Hornstock’s insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help

When pathology students work with the team on a cold case, their findings impact the entire Rosewood family.

A mysterious death in an empty high-rise pulls Rosie and Villa into the inner circle of a former child star who may be planning a comeback. Meanwhile, Rosie is feeling the effects of Donna's involvement at Magic City Lab, and shocking revelations from Hornstock and Rosie elevate their relationship to a new level.

Rosie, Villa and TMI head to a small town to investigate the murder of its former mayor. Rosie struggles with feelings of guilt, as Slade faces complications following his kidney donation