Rosewood’s partnership with Villa faces an uncertain future when she’s paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can’t shake the feeling that his “replacement” knows more about the victim’s narcotics business than he’s letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks, is brought in to help with the investigation and Hornstock’s insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help

When an escape artist is found dead in a wooden trunk, Rosewood and Villa must unravel a case packed with illusions and deception. Meanwhile, Hornstock's days with the East Miami PD may be numbered and Rosewood gets to know Adrian to make sure he is the right guy for Villa.

Rosewood and Villa are pulled into the world of human trafficking to investigate the death of a school teacher, and a surprising insight into Slade's past draws Rosie and Villa closer than ever before.