A decoded tattoo leads the team to a mysterious cache of dolls which turn out to be vehicles for biological weapons being sent around the world and now to the FBI. Jane exploits the fear of the weapons to advance her own plan to recover Shepherd.
The murder of a best-selling true crime novelist sends Jane and the team on a hunt for a serial killer detailed in the author's final manuscript, which also features lightly fictionalized versions of the FBI team.
Roman's clues lead to a billionaire hypochondriac with stem cells that could cure Jane, who is now on her deathbed. Patterson and Rich offer to trade the Book of Secrets for the stem cells -- but first they'll have to get it.
The team discovers an international conspiracy when a deadly weapon is stolen, Jane supports Weller when someone from his past dredges up painful memories, and Patterson and Rich contend with their newly released hacker accomplice.