A beautiful, naked amnesiac is found in Times Square covered in mysterious tattoos, including one bearing the name of FBI Agent Kurt Weller. Special Agent Weller and his FBI team must decode the map of clues on Jane Doe's body in order to thwart a deadly terrorist attack. Who is Jane Doe - is she an asset or enemy? Who wiped her memory? And who is behind the tattoos?

Jane reels from a series of massive revelations about her tattoos and grapples with whether to trust Oscar. Meanwhile, a tattoo leads the team to a shocking discovery in the Black Sea.

After a tip reveals there's a mole within the FBI's New York Office, the team must hunt for the operative while facing extreme scrutiny from Inspector Fischer. The team's deepest secrets threaten to be exposed, and everyone is a potential suspect - but some, especially Jane Doe have more to hide.

In order to stop a terrorist group from procuring a deadly chemical weapon, the team must remember key details from their first days at the FBI. Meanwhile, Weller worries after he gets scary news about the health of his daughter.