A hacker demanding a ransom payment shuts down the hospital computer system, forcing the doctors to diagnose patients without the aid of technology. A stressed Goodwin struggles to keep the hospital afloat when an unexpected visit from her ex-husband Bert and his new girlfriend make matters worse. Making use of his former navy experience, Dr. Choi and Noah have to locate a bullet inside a patient with a gunshot wound. Meanwhile, Sarah feels Dr. Charles may be trying to push her out and Robin's unusual behavior worries Dr. Rhodes.

Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps Bert understand Lyla's sickness.

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information concerning Dr. Reese's father.

Dr. Choi and Dr. Marcel don't see eye-to-eye over the treatment of a patient's chronic pain and rumors start to circulate about Maggie. Dr. Manning works to help a young boy, but her treatment suggestions are challenged by the parents who believe in only using holistic remedies.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

Maggie gets unsettling news about a new friend and breaks protocol to support him. One of the doctors from the Med family is rushed into emergency surgery after a violent assault. A social media influencer lets his users vote on medical advice, forcing Dr. Charles to make a decision.

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie’s memory from the accident starts to return.

Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend to a police officer with a mysterious gunshot wound to the abdomen. Relationships are put to the test as secrets are revealed.

Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer’s is brought into the E.D. Maggie and Ben become concerned when one of Ben’s students is admitted. Dr. Manning and Dr. Marcel treat a terminally ill patient and disagree over the best course of action.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.