The hospital is forced to evacuate when a toxic chemical is brought into the E.D., leaving patients and the staff in grave danger. Stuck in an elevator, Dr. Charles and Dr. Manning are forced to take drastic measures with a pregnant woman. Goodwin is tasked with making difficult choices and Dr. Rhodes discovers a secret that Dr. Bekker has been holding from him.

Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself. Dr. Rhodes throws some serious accusations at Dr. Bekker. Dr. Halstead has suspicions about Natalie’s new boyfriend and Dr. Choi tends to Bernie.

The team deals with the aftermath of a school bus crash. Dr. Charles worries Dr. Halstead is putting his medical license in jeopardy. Maggie helps a friend in need.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Charles helps Dylan with a longtime patient who was recently diagnosed with schizophrenia. Stevie, Maggie and Vanessa investigate the legitimacy of a patient’s cancer diagnosis. Crockett is caught off-guard. Will pitches a new medical technology.

The hospital is in disarray when the janitors go on strike. Marcel treats a young girl injured on her family's farm. Charles and Cuevas' schizophrenic patient returns to Med.