Goodwin tasks Dr. Charles with evaluating a patient as a possible heart recipient, while Jeff makes a confession to Dr. Manning. Dr. Choi deals with two MMA fighters who are brought into Chicago Med in bad shape. Elsewhere, Dr. Stohl returns to the hospital from his sabbatical leave and immediately offers up different medical opinion regarding the treatment of a patient under the care of Dr. Halstead. April discovers her TB medication may lead to further complications.

Dr. Rhodes and Dr. Charles' heart transplant patient gets into a car crash, revealing issues that could complicate her surgery. A past arrest causes trouble for Maggie when the arresting officer is brought to Chicago Med with a serious injury. Elsewhere, Dr. Manning and Dr. Halstead must defend their actions when explaining a patient's cause of death. Meanwhile, Dr. Halstead attempts to treat an uncooperative horse jockey.

It's a long night on the graveyard shift at Chicago Med, especially for Dr. Reese, who must deal with pronouncing patients dead on more than one occasion. April gets called in to work, much to the dismay of Tate, who pressures her to slow down. Meanwhile, Dr. Charles passes along some vital news to Dr. Latham, and Goodwin asks Dr. Rhodes to work on a most unusual patient.

Dr. Manning and Dr. Charles treat a teenage girl with a rapidly changing set of symptoms that has everyone perplexed. Dr. Choi and medical student Jeff Clark encounter a 19 year-old tough guy who is brought into the hospital in severe distress. Once they establish the cause of the pain, the situation quickly turns dangerous and a resolved Dr. Reese does her best to help. Dr. Halstead must deal with a difficult case that is further complicated by Dr. Stohl, who has a camera crew following him around to shoot a promotional video spotlighting the hospital.

Dr. Rhodes fights to save a mother who's desperate to help her daughter beat cancer. Dr. Charles asks Sarah to conduct his daughter Robin's psych evaluation. When Will and Dr. Manning spend more time together at work, Nina goes to extreme measures to get Will's attention. Meanwhile, Dr. Choi puts pressure on Noah when a residency spot becomes available.

Dr. Rhodes challenges Dr. Charles and other hospital staff over the proper treatment for Robin. Dr. Manning seeks help from Det. Halstead when a sensitive case involving a young girl turns into a crime. Dr. Choi and April work together on a conflicting case. Meanwhile, Goodwin helps a friend in distress and, after eagerly awaiting, the doctors are surprised to learn who the new med resident is.

A new hotshot doctor arrives at Chicago Med causing competition for Dr. Rhodes, Dr. Halstead and Dr. Manning work together to diagnose a Syrian refugee without a medical record. When Robin is admitted back into the hospital for more complications, Dr. Reese takes a different approach to her treatment. Distracted from work because of Robin's worsening case, Dr. Charles is challenged by Goodwin and Noah hosts a graduation party that brings everyone together.

The doctors of Chicago Med take their opinions to the extreme as they try to bring justice to the perpetrator in the shooting of Dr. Charles. Dr. Halstead and Dr. Manning work on a heart-wrenching case that forces them to examine their own matters of the heart. Though Robin’s brain tumor was removed and she is discharged from the rehabilitation center, Dr. Rhodes remains on edge that her problems are not quite resolved. Meanwhile, Rhodes gets blindsided by his colleague Dr. Bekkar, Maggie sticks up for a patient and Dr. Choi and April try to navigate their new working relationship.

When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes and Ava continue to compete in the operating room, while Dr. Charles and Dr. Reese are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning and Dr. Cho can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps Bert understand Lyla's sickness.

Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning's son to like him.

After a neighbor is stabbed, Dr. Choi enlists the help of April to figure out who is the real cause of the incident. Dr. Bekker and Dr. Rhodes expertise is put to the test when Noah misdiagnoses a patient. Dr. Charles is put in an uncomfortable position when Dr. Reese's estranged father comes to him as a patient without her knowledge. Meanwhile, Dr. Manning rushes to save a baby with whooping cough.

Dr. Halstead and Dr. Manning are at odds over the care of a vegetative man; Dr. Rhodes goes behind Dr. Bekker's back to get his patient at the top of the transplant list; a woman in the waiting room falls asleep and won't wake up.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

After a shooting occurs during a block party, the staff is overrun with victims; Dr. Choi devises a new mass casualty plan; Dr. Manning struggles to stay focused when she realizes her son and nanny might have been at the scene.

Bekker takes drastic action to keep Rhodes from leaving Med for good. Meanwhile, Halstead questions Manning's feelings about their upcoming wedding, Ethan receives shocking news about his sister, and Dr. Charles mourns a loss.