The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

The doctors treat victims of a movie-theater shooting as Sharon Goodwin tries to keep the press at bay. A teen with an eating disorder is treated, but Dr. Charles' methods rub others the wrong way. The staffers deal with a racist patient.

Dr. Rhodes treats his mentor and Goodman faces personal issues in the Season 1 finale. Also: April deals with a disorderly patient; Dr. Manning's past catches up with her; and Sarah's graduation day arrives, but she remains conflicted about her future.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.

Dr. Rhodes and Dr. Charles' heart transplant patient gets into a car crash, revealing issues that could complicate her surgery. A past arrest causes trouble for Maggie when the arresting officer is brought to Chicago Med with a serious injury. Elsewhere, Dr. Manning and Dr. Halstead must defend their actions when explaining a patient's cause of death. Meanwhile, Dr. Halstead attempts to treat an uncooperative horse jockey.

It's a long night on the graveyard shift at Chicago Med, especially for Dr. Reese, who must deal with pronouncing patients dead on more than one occasion. April gets called in to work, much to the dismay of Tate, who pressures her to slow down. Meanwhile, Dr. Charles passes along some vital news to Dr. Latham, and Goodwin asks Dr. Rhodes to work on a most unusual patient.

It's a miracle when a trauma patient survives the trip to the hospital, putting the pressure on Dr. Rhodes to keep the man alive. Dr. Choi and Dr. Manning have difficulty diagnosing the location of infection in a paralyzed patient. Dr. Reese must find purpose for a grieving widower who relies on a superhero costume. Meanwhile, April pushes Dr. Halstead to use unproved medications to help a patient with no other options.

Dr. Reese is contacted for help by a troubled teen in a psychiatric facility and Dr. Manning tries to help parents make a decision about their comatose daughter's surprise pregnancy. April begins to deal with repercussions from her personal life. Meanwhile, Dr. Choi and Dr. Rhodes work to save both a young girl from Ecuador who collapsed mid-flight, as well as her mother, who made great sacrifices for her daughter.

A suicide shakes the staff. Dr. Choi and Dr. Halstead face off over how to treat a patient with stroke symptoms. Family turmoil unfolds when a boy is treated after falling in a river. The importance of learning from mistakes is emphasized to Dr. Reese.

A hacker demanding a ransom payment shuts down the hospital computer system, forcing the doctors to diagnose patients without the aid of technology. A stressed Goodwin struggles to keep the hospital afloat when an unexpected visit from her ex-husband Bert and his new girlfriend make matters worse. Making use of his former navy experience, Dr. Choi and Noah have to locate a bullet inside a patient with a gunshot wound. Meanwhile, Sarah feels Dr. Charles may be trying to push her out and Robin's unusual behavior worries Dr. Rhodes.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

Dr. Charles struggles to convince Dr. Choi that surgery isn't always the answer. Dr. Rhodes finds himself in hot water with Goodwin when he disobeys her direct order. April becomes frustrated with Maggie when she continues to question her leadership role as the stand-in charge nurse. Dr. Manning suspects Dr. Halstead is keeping something from her.

Will and Natalie prepare for their big day, but an unsuspecting Will soon finds himself sidetracked. Dr. Charles disagrees with Goodwin on how to best handle a patient's treatment while Dr. Choi and April are on their own when a pregnant woman delivers. Dr. Rhodes finds himself operating on a patient that is of great importance to Det. Halstead.

Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the E.D.

The outcome of Will's investigation weighs heavily on his mind as he works with Dylan to save a 4-month-old patient. Stevie and Vanessa both struggle to keep their secrets. Crockett and Blake work with Abrams to save a patient in need of a liver transplant.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Halstead and Asher clash over a patient in need of a kidney transplant. Marcel faces a tough decision when Blake is in surgery. Choi and Archer treat the son of Med's general counsel. Med's family grows.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Supply chain disruptions dramatically impact Med, causing Marcel to clash with other doctors. Maggie reveals something to Ben. Choi and Archer help a patient with ALS.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

A documentary crew visits Med to film Marcel and Abrams' groundbreaking surgery. Archer refuses to ask for help for his kidney issues despite the staff's unrelenting kindness.

The fate of the hospital rests on the vote of an incapacitated board member. Archer helps a mother with a rare stem cell disease while Asher treats the woman's pregnant daughter. Charles encounters a schizophrenic patient with a hearing impairment.

As Jack Dayton prepares to launch OR 2.0's IPO, Marcel and Grace search for data that may put a wrench in his plans. Charles helps a schizophrenic patient who is anxious about prom. Asher clashes with Abrams when his wife becomes her patient.