When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

The team fights to save the life of one of their own. Frost and Abrams butt heads with their patient. Asher helps a religious young woman with an ectopic pregnancy.

Goodwin struggles with the psychological aftermath of her attack. Ripley treats a patient with helicopter parents. An ED staffer makes a mistake that may cost them their job.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.