Vanessa and Archer disagree on how to handle the victim of a motorcycle accident. Dylan and Charles deal with a UNICEF negotiator with repressed trauma. Stevie and Will treat a high schooler with Addison's disease and a clingy mother.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Rival gangs bring their war to Med. Halstead and Charles work with a brain cancer patient who's refusing treatment. Tensions run high in the OR when a patient's transplanted uterus fails.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.

A brutal storm rocks Chicago. Halstead encourages Dr. Grace Song to go against her own findings for the benefit of their patient. Asher rushes to the hospital to help Archer's pregnant patient. Maggie's concern for Ben consumes her.

Halstead and Cuevas struggle to diagnose a patient with a rare disorder. CFD and Med staff work to free a paranoid father trapped in the MRI suite. Tanaka-Reed gets an ego check.

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.

Maggie clashes with Charles over a distrustful patient. Marcel and Halstead fight against Med's new policies. Asher and Archer pull surprising things out of their unsuspecting patients.