Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.

Ethan teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Vanessa and Archer disagree on how to handle the victim of a motorcycle accident. Dylan and Charles deal with a UNICEF negotiator with repressed trauma. Stevie and Will treat a high schooler with Addison's disease and a clingy mother.

Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

Dylan's loyalty to Med and the police department is challenged when an old family friend and veteran cop exhibits concerning behavior. The annual random drug testing puts a doctor’s career in jeopardy. Ethan tries a risky old-school method on a patient. Will helps Stevie search for her mother.

Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Halstead treat a patient who's been in an iron lung for 60 years.

Rival gangs bring their war to Med. Halstead and Charles work with a brain cancer patient who's refusing treatment. Tensions run high in the OR when a patient's transplanted uterus fails.

Scott helps the daughter of a mob boss. A grandmother comes to Med desperate to save her grandson. Choi struggles with some shocking news about his father.

Supply chain disruptions dramatically impact Med, causing Marcel to clash with other doctors. Maggie reveals something to Ben. Choi and Archer help a patient with ALS.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.

Goodwin and Charles clash as negotiations drag on between the administration and the custodial workers' union. Asher fights to keep a mother and her newborn baby together.

A documentary crew visits Med to film Marcel and Abrams' groundbreaking surgery. Archer refuses to ask for help for his kidney issues despite the staff's unrelenting kindness.

Maggie clashes with Charles over a distrustful patient. Marcel and Halstead fight against Med's new policies. Asher and Archer pull surprising things out of their unsuspecting patients.

A woman from Archer's past returns and threatens his transplant surgery. Marcel clashes with Med's new eager first-year resident. Charles works to repair his relationship with Ripley.