Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.