Официалното откриване на спешното отделение в болницата е прекъснато поради тежка влакова катастрофа, която подлага екипа на огромно изпитание и изцежда докрай силите им.

Итън изпада в разногласия с Натали и Шарън, когато се заема с лечението на невръстна майка, изоставила своето новородено на улицата.

Конър е принуден да се изправи срещу миналото си, когато поема случая на близък семеен приятел, тежко пострадал от строшени стъкла.

След стрелба в киносалон лекарите от екипа работят трескаво по спасяването на пострадалите, докато Шарън се опитва да удържи наплива на медиите.

Д-р Роудс и д-р Занети се надпреварват с времето, за да спасят пострадал пожарникар, когато се оказва, че случай на бореща се за живота си жена е много сходен с тези на други пациенти.

Шарън е посетена от представители на Службата за вътрешна сигурност във връзка с двама самолетни гратисчии, които са докарани в болницата с тежки наранявания.

Шарън трябва да реши дали да рискува работата си заради нуждаещ се пациент.

Саудитски принц пристига за хирургична процедура, докато д-р Манинг се връща от майчинство и се заема с лечението на тийнейджър с дълга история на здравословни проблеми.

Д-р Холстед застрашава кариерата си, когато въпреки желанието на семейството му, реанимира умиращ от рак пациент.

Д-р Роудс и д-р Дауни загърбват различията си, за да оперират герой от 11-и септември, страдащ от пулмонална фиброза.

Д-р Роудс и д-р Чой имат несъгласия относно молбата на умиращ пациент.

Сестра Локууд е арестувана заради отказа си да вземе кръв от пациент, заподозрян в шофиране в нетрезво състояние, без той да е дал съгласието си.

Д-р Холстед и Шарън Гудуин се занимават със съпруг, който настоява да вземе яйцеклетки от наскоро починалата си съпруга, докато д-р Чарлз и д-р Чой трябва да помогнат на пациент, който иска да отреже ръката си, тъй като не я чувства като своя.

Д-р Чой и д-р Чарлс са с пациент, който твърди, че сърцето му бие в главата му, докато д-р Манинг подозира, че младо момче със счупена китка има доста по-сериозни проблеми.

Д-р Манинг и д-р Чарлс попадат на 16-годишен пациент, който се оплаква от стомашни болки и отказва да приема лекарства, а в това време д-р Халстед лекува свой стар съученик.

Д-р Роудс и д-р Дауни имат несъгласия относно спешна сърдечна операция на пациент.

Ейприл и д-р Халстед лекуват бездомен алкохолик със счупен крак.

Д-р Роудс лекува д-р Дауни, докато д-р Халстед получава отговори от Гудуин.

Лекарите от Чикаго преживяват различни промени.

Д-р Чой наставлява флотски санитар, докато два случая с бебета може да се окажат свързани.

При посещението на сестрата на Маги биват разкрити стари семейни тайни.

Дъщерята на д-р Чарлз се занимава със случаи на рядка инфекция, когато започва работа в отдела по епидемиология.

Инцидент на чикагския маратон налага спешната намеса на медицинския персонал.

Д-р Манинг се грижи за пациентка с рак и трябва да я информира за тежкото ѝ състояние.

Детската любов на Шарън пристига в болницата, докато Холстед се опитва да въведе в ред финансите си.

Д-р Холстед и д-р Манинг се занимават с двама враждуващи братя, които са докарани заедно и единият се оказва крайно нуждаещ се от бъбрек.

Гудуин моли д-р Чарлз да прецени дали пациент може да бъде възможен реципиент на сърце, докато Джеф споделя нещо важно с д-р Манинг.

Пациентът за трансплантация на сърце на Д-р Роудс и д-р Чарлз претърпява автомобилна катастрофа. Вследствие на това се разкриват някои усложнения в състоянието ѝ, които могат да доведат до проблеми при операцията.

Очертава се дълга нощ за среднощната смяна в Чикагската болница. Особено за д-р Рийс, който трябва да приеме факта, че е необходимо да обяви няколко пациенти за починали при различни обстоятелства.

Д-р Манинг и д-р Чарлз лекуват тийнейджърка, която обърква всички лекари с непрекъснатата промяна на симптомите си. Междувременно студентът на д-р Чой поема нов случай с 19-годишен пациент, изпитващ силна болка.

Д-р Роудс убеждава д-р Лейтъм да се присъедини към него за медицински случай в съседен град. По време на пътуването им проблемите на Лейтъм са подложени на изпитание.

Лекарите и сестрите от чикагската болница са притиснати и подложени на сериозно изпитание, когато лечебното заведение е препълнено с пациенти от верижна катастрофа.

Случва се истинско чудо, когато тежко пострадал пациент оцелява при транспортирането до болницата и попада в ръцете на д-р Роудс, който се бори за живота му.

Д-р Рийс е повикан да помогне на проблемен тийнейджър в психиатрична клиника, докато д-р Манинг се опитва да даде съвет на родители, чиято дъщеря в безсъзнание се оказва бременна.

Д-р Чой и д-р Холстед са изправени пред нуждата от решение как да лекуват пациент със симптоми на удар, д-р Манинг лекува младо момче, което е паднало в реката, а д-р Роудс преглежда човека, който е спасил пациента на д-р Манинг от удавяне.

Уил е изправен пред трудна морална дилема, когато бившата му учителка д-р Бела Роуан е заплашена от смъртоносна болест.

Хакер спира компютърната система в болницата с искане на откуп, което принуждава лекарите да диагностицират пациентите без помощта на технологиите.

Нещата стават прекалено лични за д-р Холстед, когато неговият отчужден баща е приет за лечение в болницата против волята си.

Д-р Роудс се бори за живота на майка, която отчаяно иска да помогне на умиращата си дъщеря, докато д-р Чарлз моли Сара да извърши психологическа оценка на дъщеря му Робин.

Д-р Роудс отправя предизвикателство към д-р Чарлз и други от болничния персонал във връзка с определянето на подходящото лечение на Робин.

В Чикагската болница пристига нов напорист лекар, който влиза в съперничество с д-р Роудс.

The doctors of Chicago Med take their opinions to the extreme as they try to bring justice to the perpetrator in the shooting of Dr. Charles. Dr. Halstead and Dr. Manning work on a heart-wrenching case that forces them to examine their own matters of the heart. Though Robin’s brain tumor was removed and she is discharged from the rehabilitation center, Dr. Rhodes remains on edge that her problems are not quite resolved. Meanwhile, Rhodes gets blindsided by his colleague Dr. Bekkar, Maggie sticks up for a patient and Dr. Choi and April try to navigate their new working relationship.

Dr. Manning goes to extremely measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake.

When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes and Ava continue to compete in the operating room, while Dr. Charles and Dr. Reese are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning and Dr. Cho can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps Bert understand Lyla's sickness.

Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning's son to like him.

After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.

After witnessing a drive-by shooting and hitting her head, Dr. Manning struggles with the aftermath of a head injury. Complicating matters, she and Dr. Halstead deal with a teenage patient and her overbearing older husband, who might not be looking out for his young wife's best interests. Dr. Rhodes finds himself in a unique situation when he learns alarming information about the woman he went on a date with. Maggie is surprised to discover some unexpected things about the man she has been seeing. Dr. Charles is frustrated when Dr. Reese disobeys his orders and puts herself at risk.

After a neighbor is stabbed, Dr. Choi enlists the help of April to figure out who is the real cause of the incident. Dr. Bekker and Dr. Rhodes expertise is put to the test when Noah misdiagnoses a patient. Dr. Charles is put in an uncomfortable position when Dr. Reese's estranged father comes to him as a patient without her knowledge. Meanwhile, Dr. Manning rushes to save a baby with whooping cough.

Upon hearing news of a pregnant teen, Dr. Manning and Dr. Choi venture to a homeless encampment to help deliver a baby under dire circumstances. Dr. Rhodes and Dr. Bekker argue about the best way to treat a young boy with a chronic disease. Dr. Halstead and April are put in an uncomfortable situation when they find out their patient is a pedophile. Goodwin and Maggie have to deal with a lawsuit against the hospital. Dr. Charles learns of important news pertaining to Dr. Reese's father.

Dr. Halstead and Dr. Manning are at odds over the care of a vegetative man; Dr. Rhodes goes behind Dr. Bekker's back to get his patient at the top of the transplant list; a woman in the waiting room falls asleep and won't wake up.

After a baby is abducted from Med, Goodwin enlists the help of Dr. Charles and Dr. Reese to find the suspect. Due to the lockdown, Dr. Rhodes must figure out a way to get into the operating room to help perform open-heart surgery. Dr. Manning and Dr. Halstead disagree on the right treatment for a patient.

Dr. Charles and Dr. Reese search for answers when a mother brings in her daughter claiming she is possessed. Dr. Rhodes and Dr. Bekker are tasked with finding a way to save a pair of conjoined twins. Dr. Halstead struggles to get Dr. Manning's attention. Maggie measures her options in the wake of her recent actions.

After taking the lead on a surgery, Dr. Bekker feels the heat after something goes wrong. Dr. Manning and Dr. Charles are faced with a tough decision concerning the gender of a 9-year-old girl. April and Dr. Reese rush to find the son of a dying patient. Goodwin's godson is admitted to the hospital.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

After a shooting occurs during a block party, the staff is overrun with victims; Dr. Choi devises a new mass casualty plan; Dr. Manning struggles to stay focused when she realizes her son and nanny might have been at the scene.

Dr. Manning rushes to save a young boy with a life-threatening case of the flu; April suspects Dr. Choi's sister stole opioid pain killers; Dr. Rhodes and Dr. Bekker disagree over the best treatment for a cardiac patient who is 21 weeks pregnant.

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information concerning Dr. Reese's father.

Bekker takes drastic action to keep Rhodes from leaving Med for good. Meanwhile, Halstead questions Manning's feelings about their upcoming wedding, Ethan receives shocking news about his sister, and Dr. Charles mourns a loss.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

When a sick boy is brought in, Ethan is faced with a tough decision that quickly escalates into a complicated and dangerous situation. Connor and Maggie are put to the test, while Natalie and Ethan aren't sure what to make of Elsa, the new third year medical student.

Dr. Halstead gets an unplanned visit from the CPD while Ethan is skeptical of a woman who is experiencing chronic pain. Natalie tends to a cancer patient whose brother has strong feelings on why he is refusing to lend his assistance

When things become complicated, Will is forced to lie to Natalie. Ethan and April find out some compromising information about Emily's boyfriend and Ava is unsure of what to do with a patient who is refusing treatment.

Dr. Manning and Dr. Halstead become skeptical of a patient's injuries when the victim of a car accident is brought into the hospital. Ethan and April have a difficult time understanding Emily's attachment to her boyfriend despite recent developments. Will and Natalie brace for their joint bachelor/bachelorette party.

The hospital is forced to evacuate when a toxic chemical is brought into the E.D., leaving patients and the staff in grave danger. Stuck in an elevator, Dr. Charles and Dr. Manning are forced to take drastic measures with a pregnant woman. Goodwin is tasked with making difficult choices and Dr. Rhodes discovers a secret that Dr. Bekker has been holding from him.

Dr. Charles struggles to convince Dr. Choi that surgery isn't always the answer. Dr. Rhodes finds himself in hot water with Goodwin when he disobeys her direct order. April becomes frustrated with Maggie when she continues to question her leadership role as the stand-in charge nurse. Dr. Manning suspects Dr. Halstead is keeping something from her.

Will and Natalie prepare for their big day, but an unsuspecting Will soon finds himself sidetracked. Dr. Charles disagrees with Goodwin on how to best handle a patient's treatment while Dr. Choi and April are on their own when a pregnant woman delivers. Dr. Rhodes finds himself operating on a patient that is of great importance to Det. Halstead.

April finds herself in a dangerous situation and Natalie gets an update on Will. Dr. Rhodes gears up for a gala honoring his hybrid O.R. and tries to convince Dr. Bekker to join him.

Halstead takes heat for making an unauthorized move to treat his pregnant patient. Choi becomes personally invested when treating a homeless veteran. Rhodes and Bekker deal with a patient who desperately needs a liver transplant.

Dr. Halstead rushes to rescue Dr. Manning after she is involved in a Medevac helicopter crash. The personal drama between Dr. Rhodes and Dr. Bekker boils over. Dr. Charles and Dr. Choi work to help a patient come to terms with their addiction. April helps Elsa deal with the loss of her first patient.

Halstead hides the theft of his gun from a suspicious Manning. Tensions are still high between Connor and Bekker, who take a risk operating on an HIV-positive patient. Hank breaks down when he sees a patient from his past.

Connor, who is in hot water with the hospital's Oversight Committee, handles a gunshot victim with unexpected ties to Halstead. Maggie feels guilty about the return of a former patient. Charles has an awkward first date.

Natalie and Maggie witness a pickup truck plow through a street fair and must make tough decisions on the fly. At the hospital, doctors and nurses are on high alert with the influx of patients. Dr. Charles' ex-wife comes to town with news.

Halstead treats a woman on the verge of freezing to death. Dr. Charles' ex-wife receives some concerning news. Choi handles a lymphoma patient with viral meningitis and a complicated family. Manning makes a house call.

When a car unexpectedly smashes through the ambulance bay doors, Dr. Choi makes some difficult decisions in an effort to save a worker trapped beneath the wreckage and April, who's also in danger.

Dr. Rhodes receives an alarming phone call that prompts him to rush out in the middle of an important surgery. Dr. Halstead comes to the aid of an FBI agent who is brought into the ER, but he suspects there is more to the story than he is being told. Dr. Manning and Dr. Choi find themselves on opposite sides of a major disagreement over doctor-patient confidentiality.

The hospital goes into lockdown mode when a man with a gun holds medical staff hostage. Goodwin is forced to make a tough decision. Dr. Rhodes begins to realize his time with his father is getting short.

Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself. Dr. Rhodes throws some serious accusations at Dr. Bekker. Dr. Halstead has suspicions about Natalie’s new boyfriend and Dr. Choi tends to Bernie.

Caroline has news to share, forcing Dr. Charles to make a serious decision about their relationship. Maggie meets her sister's new boyfriend, but discovers danger may lie ahead. Dr. Rhodes experiences a devastating loss while Dr. Choi and April are faced with an unexpected challenge that strengthens their relationship.

Dr. Charles and Caroline set some major plans. Ava fights to keep her relationship with Connor. Agent Lee informs Will of news that may put his life in danger.