Goodwin tasks Dr. Charles with evaluating a patient as a possible heart recipient, while Jeff makes a confession to Dr. Manning. Dr. Choi deals with two MMA fighters who are brought into Chicago Med in bad shape. Elsewhere, Dr. Stohl returns to the hospital from his sabbatical leave and immediately offers up different medical opinion regarding the treatment of a patient under the care of Dr. Halstead. April discovers her TB medication may lead to further complications.

Dr. Rhodes and Dr. Charles' heart transplant patient gets into a car crash, revealing issues that could complicate her surgery. A past arrest causes trouble for Maggie when the arresting officer is brought to Chicago Med with a serious injury. Elsewhere, Dr. Manning and Dr. Halstead must defend their actions when explaining a patient's cause of death. Meanwhile, Dr. Halstead attempts to treat an uncooperative horse jockey.