Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.

Dr. Rhodes challenges Dr. Charles and other hospital staff over the proper treatment for Robin. Dr. Manning seeks help from Det. Halstead when a sensitive case involving a young girl turns into a crime. Dr. Choi and April work together on a conflicting case. Meanwhile, Goodwin helps a friend in distress and, after eagerly awaiting, the doctors are surprised to learn who the new med resident is.