Nurse Lockwood gets arrested when she takes a stand. Meanwhile, Dr. Halstead deals with a pending lawsuit against him; a baby's injuries come into question; Dr. Charles faces personal issues; and suspicions rise about a patient who was hit by a car.

Dr. Rhodes fights to save a mother who's desperate to help her daughter beat cancer. Dr. Charles asks Sarah to conduct his daughter Robin's psych evaluation. When Will and Dr. Manning spend more time together at work, Nina goes to extreme measures to get Will's attention. Meanwhile, Dr. Choi puts pressure on Noah when a residency spot becomes available.