Nuclear scientists mysteriously disappear when Vandal Savage retreats behind the Iron Curtain in the early 1980s. The team follows Vandal's trail in an effort to find his next target, while Ray bonds with a beautiful Soviet scientist. Stein pushes Jax to be better, which frustrates Jax and ultimately threatens the Firestorm matrix. Rip asks Sara to train Kendra.

The team tracks Savage to a small town in Oregon during the 1950s. Upon arrival, they discover there have been a recent string of murders and they suspect Savage is involved. Professor Stein and Sara go undercover at a psychiatric hospital, where Savage is working as a doctor, to find out his plan. While there, Sara meets a nurse named Lindsay and sparks fly. Meanwhile, Ray and Kendra pretend to be a married couple to gain the neighborhood’s trust, but an interracial couple in the ‘50s isn’t something that goes unnoticed. Soon, Savage is at their door.

Rip takes the team to London in the year 2166, three months before his family is killed. He believes this to be their final opportunity to take out Savage who is, unfortunately, at the height of his power. However, the team discovers two key elements to defeating him – Savage’s daughter and the means to kill Savage once and for all.

The Legends travel to Nazi-occupied Paris and are surrounded by the Justice Society of America. They discover a time aberration that threatens the JSA, but the JSA doesn't want their help. Meanwhile, Nate tries to prove he should be part of the team.

When a new Time Aberration is discovered by the Legends, they find themselves headed to 1927 Chicago. The Legends quickly realize that they have been set up by Eobard Thawne, Damien Darhk and the newest member of the Legion of Doom, Malcolm Merlyn. While everyone is trying to help fix what they think is the mission, Jax encourages a reluctant Stein to share his secret with the other Legends. Stein is taken captive and Sara must make the tough choice of either stopping the Legion of Doom or saving Stein. Meanwhile, Rory gets an unexpected visitor and is not sure how to handle it.