Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of “the hybrids,” an army of unstoppable lab-made creatures focused on destroying mankind.
Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham’s research into the sterility crisis endangers his family.
The team sets out on a rescue mission for Abe and Dariela’s son, Isaac. Then, in search of information on a new hybrid, Mitch and Jamie travel to California, where they cross paths with a familiar face from their past.
Abigail holds Jackson prisoner in order to extract information from him that is critical to her secret master plan, and the team faces a mid-air crisis when their plane experiences an electrical malfunction