Following a shift in violent animal behavior, the team attempt to rescue Jamie and secure the leopard that could hold the key to curing the animal crisis.

In an effort to unravel a dark conspiracy within the Noah Objective, the team travels to Vancouver, where it must infiltrate a black-tie event in order to get close to General Davies and stave off an impending animal threat. Also, Jamie and Logan's journey is interrupted when Logan's past comes back to haunt them.

Mitch digs into Jackson’s past to get the answers they need to make the cure. Also, the rest of the team hunts for evidence related to the triple helix inside a quaint English town.

Mitch and Jamie brave an animal attack at the Russian Embassy in Washington, D.C., and Jackson finally gets the answers he’s been looking for from a surprising source.

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.

Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of “the hybrids,” an army of unstoppable lab-made creatures focused on destroying mankind.

While Jamie’s under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans

As the team is trapped inside the plane by toxic spores surrounding them, complications arise during the delivery of Clementine’s baby.