An epidemic of unknown origin strikes mankind, killing all adults and rendering the youngsters at the mercy of the vampire kind. Four years later, Yūichirō Hyakuya and his friends make a daring attempt to escape from the vampires, unaware that a mortal trap awaits them.

Yūichirō and his companions arrive at Shinjuku to help repel the vampire offensive, while Guren's party spots Mikaela and Ferid, and decides to face them.