Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.

A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.

Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor (guest star Alec Mapa) of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder (guest star Cheri Oteri) leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.