All hell is about to break loose on the Wallace University campus when, exactly 20 years after a mysterious tragedy, a devil-clad killer begins to target the sisters of Kappa House. The super-charged comedy-horror series is a modern take on the classic whodunit with a killer cast. With at least one casualty each week until the mystery is solved, anyone could be the next victim – or the murderer.

Twenty years after a mysterious death rocks Wallace University, another murder takes place.

Mens Chanel plager de nye ansøgere, fortsætter mordene. Gigi beslutter sig for at hyre sikkerhedsfolk, for at beskytte søstrene. "En djævleklædt morder laver ravage ved at tage et offer i hvert afsnit. Scream queens er halvt sort komedie og halvt gyser, en moderne vinkel på den klassiske ""hvem gjorde det"", hvor alle roller har et motiv for at slå ihjel. .. .eller til at blive det næste blodtilsølede offer."

Chanels seneste projekt er Hester. Chanel har en tilståelse, hun er nødt til at komme ud med. Grace og Zayday opdager en rystende forbindelse mellem to medstuderende.

Da Halloween nærmer sig kommer Zayday med en fantastisk deklaration og Chanel bager på endnu en lusket plan.

Rektor Munsch kommer med en meddelelse, som får indflydelse på Chanels planer om at hode græskarfest. Pete og Grace leder efter deres ven.

I et forsøg på at beskytte sig selv, tager Chanel en beslutning, der giver magten til Zayday. Pigerne i Kappa Kappa Tau udsættes for en chokerende opdagelse under en pyjamasfest.

En chokerende hændelse, gør at rektor Munsch pludselig står ansigt til ansigt med sin eks-mands elskerinde.

Grace bliver klogere på Chanel, mens de samarbejder om at efterforske KKKs fortid. Rektor Munsch bliver næste mål og en karakter fra fortiden chokerer ved at komme tilbage.

Denise fortæller rædselsvækkende spøgelseshistorier. Hesters bekendtgørelse skubber Chanel ud over kanten. Et kendt ansigt vender tilbage og morderen gør krav på endnu et offer.

Chad takes Chanel to his family home for Thanksgiving, where she meets his brothers, Brad and Thad, as well as his parents. However, an uninvited guest throws the holiday into chaos. Meanwhile, Dean Munsch gathers the survivors at Kappa House, but dinner quickly explodes into accusations of who among them is really the killer. Then, the Red Devil carves up a deadly main course as another victim falls.

Den røde djævel har planer om at ødelægge den fridag, Chanel elsker allermest: Black Friday. Denise får et andet job. Pet modtager et tilbud fra Chad og der falder en tilståelse.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.

A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.

Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor (guest star Alec Mapa) of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder (guest star Cheri Oteri) leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.

After the latest attack by The Green Meanie leaves everyone shocked and saddened, Dean Munsch and Denise, along with Hester, devise a plan to catch the killer by throwing a Halloween party in the hospital. Meanwhile, Chanel celebrates a different kind of Chanel-O-Ween and attempts to make contact with the killer’s latest victim from beyond the grave. Once the party begins, an outbreak surprises the hospital, leading Brock and Cassidy to jump into action, and another victim falls.

The frightful events of Halloween force Dean Munsch to notify authorities of murders at the Institute, which leads to a surprising influx of new patients. Meanwhile,Chanel is tired of doing dirty work, so she concocts a plan that entails recruiting new patients to join the Chanels. Later, Zayday and Chanel #5 visit a person with ties to the hospital's past; and a new patient's problems have the staff going a bit mad.

After an influx of patents at the C.U.R.E. institute, Dean Munsch and Chanel organize a blood drive to solve the hospital's severe shortage. Meanwhile, Nurse Hoffel sets a plan of revenge in motion, Hester finds a way to join the hospital's staff and a shocking revelation involving The Green Meanie occurs.

In an effort to secure positive press for the hospital, Dean Munsch pitches a risky surgery to Dr. Holt, whose hand begins expressing more of a wild and dangerous personality than ever before. Meanwhile, Chanel #3 forces Cassidy to undergo a psych test to find the root of his condition with surprising results, and Nurse Hoffel sets a devious plan in motion.

A man from Dean Munsch's past checks in to the C.U.R.E. institute with plans to win her back, causing a jealous Brock to further question his relationship with Chanel. Meanwhile, Zayday and Chamberlain devise a plan to discover the origins of The Green Meanie killer with shocking results.

The Chanels are overwhelmed when their TV idol, Dr. Scarlett Lovin, visits the C.U.R.E. Institute. Meanwhile, Hester calls a Green Meanie summit as the killer(s) put their final kill plan into effect.

The Green Meanie sets its final plan for revenge in motion as Hester makes a bold move to secure her future, and Brock performs a dangerous surgery to save Dean Munsch's life.