All hell is about to break loose on the Wallace University campus when, exactly 20 years after a mysterious tragedy, a devil-clad killer begins to target the sisters of Kappa House. The super-charged comedy-horror series is a modern take on the classic whodunit with a killer cast. With at least one casualty each week until the mystery is solved, anyone could be the next victim – or the murderer.

La serie antologica comedy-horror inizia con la storia di un campus universitario in cui si sta verificando una catena di omicidi.

Un serial-killer continua a perseguitare le ragazze di una stessa confraternita.

Chanel usa Hester come suo nuovo progetto e Chanel #3 confessa un segreto. Mentre Grace e Zayday notano un feeling sorprendente tra due studenti, la decana Munsch trova una nuova mascotte. E Chad ed Earl Grey riuniscono la confraternita per iniziare una caccia alle streghe...

Il sorprendente annuncio di Zayday scatena il diabolico piano di Chanel; Grace e Pete fanno visita a una donna misteriosa con un passato Kappa; Hester e Chad diventano sempre più intimi. Intanto Denise continua a cercare il Diavolo Rosso, mentre Dean Munsch cerca il modo di tenere aperta l'università.

L'annuncio di Dean Munsch per Halloween ha delle conseguenze sull'intero campus e sul piano di Chanel di organizzare una festa per promuovere la sua campagna elettorale. Intanto Grace e Pete mettono insieme una squadra di ricerca per ritrovare una persona scomparsa, avvicinandosi così al Red Devil. E Chanel #3 e #5 sperimentano come sarebbe la loro vita senza Chanel.

Chanel prende una decisione inaspettata e, come risultato, Zayday ci guadagna. Intanto le ragazze del Kappa Kappa Tau organizzano un pigiama-party.

Un evento scioccante induce Dean Munsch a un faccia a faccia con l'amante del suo ex-marito. Intanto le Kappa ricorrono a un quadrante degli spiriti per scoprire quale sia l'identità del serial killer e comunicare con Chanel #2 dall'aldilà...

Quando Grace chiede aiuto a Chanel per sapere di più sul passato delle KKT, si rende conto di non essere poi così diversa da lei. Dean Munsch, intanto, non la prende bene quando finisce nel mirino dei Red Devils. E una spaventosa figura riemerge dal passato.

Denise si inventa una spaventosa storia di fantasmi per le Kappa, Chanel sta per crollare dopo lo scioccante annuncio di Hester e un volto noto riappare al campus quando i Red Devil tornano a colpire.

Chad takes Chanel to his family home for Thanksgiving, where she meets his brothers, Brad and Thad, as well as his parents. However, an uninvited guest throws the holiday into chaos. Meanwhile, Dean Munsch gathers the survivors at Kappa House, but dinner quickly explodes into accusations of who among them is really the killer. Then, the Red Devil carves up a deadly main course as another victim falls.

È il primo giorno di saldi e le Chanel vanno a fare shopping, ma il Red Devil è pronto a demolire la loro frenesia di spese. Intanto le Kappa escogitano un piano per fermare Dean Munsch, mentre Denise trova un nuovo lavoro e qualcuno confessa un omicidio.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.

A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.

Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor (guest star Alec Mapa) of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder (guest star Cheri Oteri) leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.

After the latest attack by The Green Meanie leaves everyone shocked and saddened, Dean Munsch and Denise, along with Hester, devise a plan to catch the killer by throwing a Halloween party in the hospital. Meanwhile, Chanel celebrates a different kind of Chanel-O-Ween and attempts to make contact with the killer’s latest victim from beyond the grave. Once the party begins, an outbreak surprises the hospital, leading Brock and Cassidy to jump into action, and another victim falls.

The frightful events of Halloween force Dean Munsch to notify authorities of murders at the Institute, which leads to a surprising influx of new patients. Meanwhile,Chanel is tired of doing dirty work, so she concocts a plan that entails recruiting new patients to join the Chanels. Later, Zayday and Chanel #5 visit a person with ties to the hospital's past; and a new patient's problems have the staff going a bit mad.

After an influx of patents at the C.U.R.E. institute, Dean Munsch and Chanel organize a blood drive to solve the hospital's severe shortage. Meanwhile, Nurse Hoffel sets a plan of revenge in motion, Hester finds a way to join the hospital's staff and a shocking revelation involving The Green Meanie occurs.

In an effort to secure positive press for the hospital, Dean Munsch pitches a risky surgery to Dr. Holt, whose hand begins expressing more of a wild and dangerous personality than ever before. Meanwhile, Chanel #3 forces Cassidy to undergo a psych test to find the root of his condition with surprising results, and Nurse Hoffel sets a devious plan in motion.

A man from Dean Munsch's past checks in to the C.U.R.E. institute with plans to win her back, causing a jealous Brock to further question his relationship with Chanel. Meanwhile, Zayday and Chamberlain devise a plan to discover the origins of The Green Meanie killer with shocking results.

The Chanels are overwhelmed when their TV idol, Dr. Scarlett Lovin, visits the C.U.R.E. Institute. Meanwhile, Hester calls a Green Meanie summit as the killer(s) put their final kill plan into effect.

The Green Meanie sets its final plan for revenge in motion as Hester makes a bold move to secure her future, and Brock performs a dangerous surgery to save Dean Munsch's life.