The Goddamn George Liquor Program is a 1997 Adobe Flash cartoon series created by John Kricfalusi and starring the animated George Liquor. Liquor was spun out to his own web-based cartoon during the days when the Spümcø studio had an online presence. Michael Pataki voiced Liquor in the series. Spümcø produced eight one-minute shorts.

Premiering on October 15, 1997, The Goddamn George Liquor Program was the first cartoon series to be produced exclusively for the internet. George appeared on the series with his nephew, Jimmy The Idiot Boy; Jimmy's cousins, Slab and Ernie; Jimmy's love interest, Sody Pop; and George and Jimmy's pet dog, Dirty Dog. Without the control of a network, the series could be made as Kricfalusi wanted. The Goddamn George Liquor Program won the 1999 Annie Award for "Outstanding Achievement in an Animated Interactive Production." Later the show was being developed as a series of cartoon commercials for Pontiac Vibe. The new series remained unreleased after General Motors discontinued the Pontiac Vibe auto line in 2009.