Delivery Boy Philip J. Fry is promoted to Emperor after accidentally drinking his fluid-based predecessor.

Fry, Leela, Bender and Farnsworth have to go to Mars University where Fry has to share a room with a talking monkey, Farnsworth's last invention. The monkey becomes a real headache when he starts beating Fry in all areas. Meanwhile, Bender is hanging out with nerd robots.

When the price of titanium skyrockets, Bender pawns his titanium-rich body and lives the high life as just a head. But when the head-in-a-jar of Richard M. Nixon uses Bender's body to run for election for President of Earth, Bender vows to get his rightful property back.

A fishing trip over the ocean takes a turn for the worse when a colossal mouth bass pulls the Planet Express ship to the bottom of the sea. There, Fry falls in love with a mermaid named Umbriel, and the crew discovers the sunken city of Atlanta, Georgia.

Fry is reunited with his old girlfriend from the 20th Century, but she doesn't adapt to the 31st century as well as he has. Convincing Fry to return to the cryogenic chamber, they awaken in a barren wasteland and struggle to make a place for themselves.

The combined explosions of a supernova and Fry putting metal in the microwave hurtle the Planet Express crew back in time to 1947. They land at Roswell, New Mexico, where a shattered Bender is mistaken for UFO debris, Zoidberg is taken in for an alien autopsy, and Fry accidentally kills his grandfather, Enis, in a nuclear explosion.

When Amy's parents' ranch is hit by a dust storm that blows away their herd of buggalo, Kif sets out to prove his masculinity by rounding up the herd, only to become entangled with the native Martians.

When Professor Farnsworth sells Planet Express to the evil Mom, it means she owns over 50% of the Earth, and becomes it's supreme ruler. It's up to Fry, Leela and Bender to save the Earth - and the universe - from Mom, as their mission takes them from New New York to alien asteroids, the surface of the sun, the farthest corner of the universe, and even though time itself!

An alien who does not understand the concept of gender conducts experiments on the crew, changing all their genders.