When a Russian dissident flees to the U.S. after contracting smallpox, Secretary of State Elizabeth McCord and retired U.N. Ambassador Kat Sandoval must work with Russian Foreign Minister Konstantin Avdonin to contain the outbreak.

Elizabeth must watch what she says and does when she deals with a refugee situation while being shadowed by Neal Shin, a newspaper reporter who may use his access to write a tell-all book.

A NATO ally carries out a state-sponsored assassination attempt against one of its own citizens, who is also a U.S. resident and old friend of Elizabeth’s. Also, Alison starts dating the son of one of Elizabeth’s political rivals.

As Elizabeth prepares to officially declare her candidacy for president, she must deal with fallout from a news article alleging she had an affair with President Dalton during her CIA days. Also, Mike B. and Jay adjust to the growing pains in their expanded roles as campaign staffers, and Elizabeth calls for a UN criminal tribunal against Myanmar military leaders over their treatment of the Rohingya.