When a Russian dissident flees to the U.S. after contracting smallpox, Secretary of State Elizabeth McCord and retired U.N. Ambassador Kat Sandoval must work with Russian Foreign Minister Konstantin Avdonin to contain the outbreak.

Vice President Teresa Hurst asks Elizabeth for help when a surrogate carrying her future grandchild is arrested in Laos for human trafficking. Also, Henry tries to protect Stevie from danger when he suspects that she’s being followed by a Russian operative, and Blake deals with the demanding and costly instructions of a delegation of Japanese gardeners.

While Elizabeth is away on a retreat thinking about her presidential campaign, her staff tries to secure an international agreement to protect citizens who have been displaced due to global warming. Also, the staff works to contain a measles outbreak that threatens the life of Daisy’s daughter, Joanna.