Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.

Despite the growing tension between them, Cole and Cassie time travel to New York during World War II to track down a dangerous member of the Twelve.

When Cole and Cassie are stranded in 1944, Jones must turn to the person she trusts the least to bring them home -- Ramse. For Ramse, this mission will give him a chance to atone for his sins -- but can he mend the broken relations between Cole and Railly? Meanwhile, Jones visits Old Jennifer Goines to explore the true nature of Time - and the Twelve’s method to destroy it.

Cole has his loyalty tested when Ramse and Railly go rogue, embarking on an unsanctioned mission that sends them to 1961 East Berlin. Once there, they have murder on their minds as they search for an unscrupulous German doctor who knows the location of "The Witness."

Out of time and in need of answers, Jennifer and Deacon are sent to 1989 to steal the a sacred document. Can Railly and Cole get to the Word first before it reveals the one secret they want kept?

In 1953, Cole and Railly reunite with Agent Gale at the birth of the Army of the 12 Monkeys.

Cassie travels back in time to confront a younger Olivia; Cole helps Jennifer find the meaning behind her final Primary vision.