It’s a real-life game of clue for Liv after she eats the brains of a despicable dowager and must determine which one of her disgruntled servants killed her. Clive and Bozzio are struggling to maintain a healthy relationship. Meanwhile, circumstances place Major and Liv in opposition to one another.

When Liv consumes the brain of a vice detective who doesn't play by the rules, her newfound recklessness gets her into trouble. Meanwhile, Major is coming really close to discovering Liv's secret.

The outside world further isolates Seattle while Peyton, Ravi, Clive and Major race to save Liv from execution for her work as Renegade.

Liv, on fitness guru brains, and Clive continue investigating a murder with no body and no evidence. Meanwhile, Peyton approaches councilman Zed with a request but doesn’t get the answer she was hoping for. Lastly, Liv surprises Major with a thoughtful gesture just when he needs it the most.

While investigating the death of independently wealthy, 19-year-old, Harris Miller, Liv, on brain à la Ferris Bueller, attempts to cheer up Ravi who has been spiraling after learning some unfortunate news. Meanwhile, after a nasty fall at the crime scene, Clive is forced to continue his part of the investigation via FaceTime. Lastly, things are suddenly going from bad to worse for Blaine.

Liv and Ravi each consume the brain of a very dislikable car salesman and inherit his competitive nature.