A young high-school girl, Ruko, receives a deck of cards, the WIXOSS. In the deck, she finds an unusual talking card. Bewildered, she meets Yuzuki, who she calls herself a "Selector." Soon, Ruko finds herself in battle to be the "Eternal Girl."

Ruko, along with her new friend, Yuzuki, come across a battle of Selectors, Akira versus Hitoe. Yuzuki must now prepare to fight the winner, Akira.

Ruko finds herself in battle against Hitoe, and taps into a desire she has never felt before. Meanwhile, Yuzuki's battle ensues against Akira.

Ruko and Yuzuki become friends with Hitoe, with hope for a lasting friendship. Akira, wanting to battle Ruko, faces her, but then Iona appears...

While waiting for Ruko and Yuzuki, Hitoe is defeated in battle. The repercussions from Hitoe's third loss is beyond Ruko and Yuzuki's imagination...

Ruko battles Akira with a resolve unlike before. Meanwhile, Yuzuki comes to a resolve on her own after a meeting with a new Selector.

As Ruko seeks answers, she comes in contact with Iona who soon senses affinity towards Ruko. Later, Ruko and Yuzuki is contacted by Akira...

After Yuzuki parts ways with Ruko, Yuzuki wins to become an Eternal Girl, but... Later, Hitoe gets a new deck of WIXOSS and finds a new LRIG...

Word spreads of the intimate, yet forbidden love Yuzuki has towards Kazuki. Meanwhile, Ruko learns the horror of what happened to the 'true' Yuzuki.

New secrets unravel with the mysterious girl, Mayu. Iona gathers the Selectors to have battles, with an ulterior motive in Iona's mind...

Ruko's battle finally comes to a close. Everyone has made a choice to their ways, and the results are...