April gets a new assignment at work and reports to a new supervisor, Raquel. Sarah urges Brenna to get an after-school job to learn more about responsibility.

April learns that Dominic has a reputation; Sara introduces her new boyfriend to the family.

April finds the going tough as she attempts to balance everything, including her first bone-marrow biopsy. Leo comes to an assumption about April's motives.

April and Dominic share family secrets with one another when they visit a psychic. George has a official diagnosis for April, whilst Sara feels she is been ignored.

April goes on a joyride with Leo before starting her treatment, and manages to gain insight into his recklessness and the severity of his illness.

April tries to remain in control of her life, despite having to check herself into chemo. Brenna tries splitting her time between Kieran and Greer.

The Carvers are thrilled to learn Natalie is a match for April, until Natalie has second thoughts. April has to re-earn her boss’s trust. Meanwhile, Brenna spends a surprising night out with Natalie, and Beth’s relationship with Graham puts her in an awkward position with Dominic.

April gets some welcome news from Dr. Hamburg that bodes well for both her and Leo. At work, she gets wind of a possible story opportunity with baseball player Richie Miranda, but when she gets a bigger scoop than she bargained for, she is faced with a tough moral choice.

April and Beth confide their doubts about each other’s boyfriends and decide to arrange a double date to get to know the guys better. April tries to hide her disappointment when Leo pulls away from the cancer support group while Beth and Graham find themselves at odds over a recent big decision. Dominic gets closer to Natalie after learning they share a sentimental connection, but Natalie worries about what April might think. Meanwhile, Sara wants to keep her latest fling easy and uncomplicated but then learns something shocking about her lover. And, after a fight with her mother, Greer turns to Brenna for support.