Barry creates a map book to guide him and Iris throughout their future in order to keep her safe, but the results are not what he expected, and instead, they relive the same day over and over again. Joe has a heart-to-heart with Cecile. A new big bad is introduced to Team Flash and friends and foes, old and new, begin to descend upon Central City.

Barry and Iris start to put together the pieces of what's happening in Central City and believe they know what the Rogues are after. Team Flash works together and recruits some unlikely allies to help, and the plan does not go as Team Flash expects. Meanwhile, Allegra does her best to avoid having a conversation with Chester.

As the Red Death wreaks havoc on Central City, Barry and Iris come up with a plan and turn to Cecile for help. Barry is faced with what he thinks was his greatest mistake and the Red Death's greatest success. Khione wants to help Team Flash, but Barry can't risk losing her. Joe gives Barry a much-needed pep talk.

Iris is visited by Nia Nal, as she needs Iris' help. When Iris and Nia fall into a fever dream and explore different possibilities for their lives, Barry, Chester, Allegra, and Cecile desperately try to help them. Meanwhile, Mark entertains Khione, but they have different ideas of what is fun, leaving Khione to feel that Mark is trying to make her something she is not.