Barry's efforts to prepare Cisco for Crisis are derailed when Cisco schemes to save Barry's life instead. Meanwhile, Ramsey Rosso uses his deadly new abilities to save his own life, while sacrificing his humanity in the process.

With The Flash freshly infected by the monstrous Bloodwork, Iris and Cisco battle to help Barry take control of himself before he’s lost forever to Ramsey’s influence. Meanwhile, the rest of Team Flash fight to reclaim control of Central City from Bloodwork’s growing army.