When all the lights go out at night the Boogie Man and his monsters come out to boogie all night long.

Mojo Jojo creates the ultimate weapons against the Powerpuff Girls. They're Brick, Boomer, and Butch: The Rowdyruff Boys, male equivalents. When regular fighting doesn't work against the Boys, the Girls have to use their feminine wiles to seal a victory.

New student Princess Morebucks comes to Pokey Oaks kindergarten and after seeing The Powerpuff Girls in action she decides to become one.

Alien broccoloids infect the broccoli of Townsville and now it's up to all the kids in Townsville(including the Powerpuff Girls) to defeat them.

Princess buys Townsville and makes crime legal.

The girls try to join the superhero organization, the Justice Friends, but they must prove themselves to do so by tests of strength, speed, and smarts. But the only flaw about the organization is it doesn't allow "little girls" into the group and it's centered around men. However, when an enemy attacks the organization, the girls must come to their rescue.